Canterbury DHB

Context

Fludarabine/TBI Conditioning

Calculation of Drug Dosages

In the seven schedules, drug dosage is related either to the patient’s actual body weight or by calculating the Body Surface area (BSA). Any dose reduction due to renal dysfunction or obesity is done by the Haematology Pharmacist in conjunction with the Transplant Consultant. See also Cytotoxic Drugs in the Drug Usage section.

Day

Summary

-5

Admit to ward.

-4

Fludarabine 30 mg/m2 Start

Cyclosporin 2 mg/kg BD PO

-3

Fludarabine 30 mg/m2

Cyclosporin 2 mg/kg BD PO

-2

Fludarabine 30 mg/m2

Cyclosporin 2 mg/kg BD PO

-1

TBI 2GY.

Cyclosporin 2 mg/kg BD PO

0

SCT infusion then start MMF.

Cyclosporin 2 mg/kg BD PO

Note: Higher doses may be given if the patient is deemed to be at high risk of relapse, e.g., Fludarabine 30 mg/m2/day x 5 or TBI 4 GY. The SCT Committee decides whether to increase the conditioning intensity.

For more details, refer to:

  • Patient-specific schedule for Fludarabine/TBI.
  • Chemo chart for Fludarabine/TBI.

About this Canterbury DHB document (9548):

Document Owner:

Andrew Butler (see Who's Who)

Issue Date:

December 2016

Next Review:

December 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 9548