Canterbury DHB

Context

Fludarabine/Melphalan/Alemtuzumab Conditioning

Calculation of Drug Dosages

In the seven schedules, drug dosage is related either to the patient’s actual body weight or by calculating the Body Surface area (BSA). Any dose reduction due to renal dysfunction or obesity is done by the Haematology Pharmacist in conjunction with the Transplant Consultant. See also Cytotoxic Drugs in the Drug Usage section.

Day

Summary

-8

Admit to BMTU

 

-7

 

Alemtuzumab 10 mg IV

-6

Fludarabine 30 mg/m2 IV

Alemtuzumab 10 or 20 mg(1) IV

-5

Fludarabine 30 mg/m2 IV

Alemtuzumab 10 or 20 mg(1) IV

-4

Fludarabine 30 mg/m2 IV

 

-3

Fludarabine 30 mg/m2 IV

 

-2

Fludarabine 30 mg/m2 IV

 

-1

Melphalan 140 mg/m2 IV

Start Cyclosporin IV

0

SCT infusion

 

For more details, refer to:

  • Patient-specific schedule for Fludarabine/Melphalan/Alemtuzumab.
  • Chemo chart for Fludarabine/Melphalan/Alemtuzumab.
  • IV fluid chart for Melphalan.
  1. For MSIB transplant give 10 mg daily on days -7, -6 and -5 (total dose of 30 mg).
    For MUD transplant give 10 mg on day -7, and 20 mg on days -6 and -5 (total dose of 50 mg).

About this Canterbury DHB document (9544):

Document Owner:

Andrew Butler (see Who's Who)

Issue Date:

December 2016

Next Review:

December 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 9544