Conditioning Schedules for SCT
Seven transplant conditioning schedules are used for most of the Stem Cell Transplants carried out at Christchurch. Occasionally other regimens are used but this is exceptional.
- Myeloablative or standard allografts are performed either following Cyclophosphamide/TBI, or Busulphan/Cyclophosphamide; Cyclophosphamide/ATG is used for aplastic anaemia.
- Cyclophosphamide/TBI is the SCT conditioning usually given for standard allografts in AML, ALL, CML, MDS, and MPD. If Cyclophosphamide/TBI is contra-indicated, or not available, Busulphan/Cyclophosphamide is used for AML, CML, MDS, and MPD.
- RIC SCT is performed following either Fludarabine/TBI, Fludarabine/IV busulphan or Fludarabine/Melphalan/Alemtuzumab:
- Fludarabine/TBI is for lower risk disease such as NHL or Myeloma.
- RIC allografting for AML/MDS uses FLAMSA-Bu as per the AML17 protocol.
- Fludarabine/Melphalan/Alemtuzumab and Fludarabine/IV busulphan is mainly for high risk disease, e.g. myeloproliferative disorders, MDS, aggressive NHL, and HD (if autograft has been unsuccessful).
- Autografts are performed following either high dose Melphalan (myeloma) or BEAM (lymphoma) conditioning.
Topic Code: 9210