Canterbury DHB


Cyclophosphamide/MESNA Detailed Schedule

Cyclophosphamide is dissolved in 1 litre 0.9% saline and given over one hour.

If the patient's actual body weight is >30% above the lean body weight then some dose reduction is usually recommended. Take the mid-point between these two weights and use this adjusted body weight for per kg dosage or for BSA calculations.

Adverse Effects

Adverse effects include: nausea and vomiting, diarrhoea, mucositis, haemorrhagic cystitis, reversible alopecia, sterility, cardiomyopathy, skin rash, fluid retention, hyponatraemia and facial discomfort.

Supportive Measures

About this Canterbury DHB document (9199):

Document Owner:

Andrew Butler (see Who's Who)

Last Reviewed:

December 2016

Next Review:

December 2018


Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 9199