Canterbury DHB
Each patient will be individually assessed to determine whether IT methotrexate should be given as part of the conditioning regimen. The usual indications are ALL, AML (especially M5), CML in accelerated phase (especially with prior CNS disease). However ALL schedules that incorporate high dose MTX prior to SCT do not require IT MTX at the time of conditioning.
Note: If methotrexate has been given in the 4 weeks prior to Day 0, folinic acid 15 mg IV Q12H should be given for 4 doses during the 48 hours prior to bone marrow infusion.
Topic Code: 9197