Canterbury DHB

Context

Busulphan/Cyclophosphamide Conditioning

Calculation of Drug Dosages

In the seven schedules, drug dosage is related either to the patient’s actual body weight or by calculating the Body Surface area (BSA). Any dose reduction due to renal dysfunction or obesity is done by the Haematology Pharmacist in conjunction with the Transplant Consultant. See also Cytotoxic Drugs in the Drug Usage section.

From 2013 oral busulphan has replaced by the intravenous formulation which eliminates variability in bioavailability and may reduce toxicity.

Day

Summary

-9

Admit to ward

-8

Cyclophosphamide 60 mg/kg

-7

Cyclophosphamide 60 mg/kg

-6

Busulphan 3.2 mg/kg IV*

-5

Busulphan 3.2 mg/kg IV*

-4

Busulphan 3.2 mg/kg IV*

-3

Busulphan 3.2 mg/kg IV*

* Dosage adjustment may be required depending on the busulphan levels.

Clonazepam is started on day -7 for seizure prophylaxis.

For more details, refer to:

  • Administration details for Cyclo/MESNA.
  • Administration details for Busulphan.
  • Patient-specific schedule for Busulphan/Cyclo.
  • Chemo chart for Busulphan/Cyclo.
  • IV fluid chart for Busulphan/Cyclo.
  • IV methotrexate for GvHD prophylaxis.

About this Canterbury DHB document (9168):

Document Owner:

Andrew Butler (see Who's Who)

Issue Date:

December 2016

Next Review:

December 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 9168