Canterbury DHB

Context

Cyclophosphamide/TBI Conditioning

Calculation of Drug Dosages

In the seven schedules, drug dosage is related either to the patient’s actual body weight or by calculating the Body Surface area (BSA). Any dose reduction due to renal dysfunction or obesity is done by the Haematology Pharmacist in conjunction with the Transplant Consultant. See also Cytotoxic Drugs in the Drug Usage section.

Day

Summary

-6

IT methotrexate 10 mg/m2 (max 12 mg) if indicated.

-5

Cyclophosphamide 60 mg/kg IV.

-4

Cyclophosphamide 60 mg/kg IV.

-3

TBI BD.

-2

TBI BD.

-1

TBI BD. Folinic acid if required. Start cyclosporin.

For more details, refer to:

  • Administration details for Cyclo/MESNA.
  • Administration details for TBI.
  • Patient-specific schedule for Cyclo/TBI.
  • Chemo chart for Cyclo/TBI.
  • IV fluid chart for Cyclo/TBI.
  • IV methotrexate for GvHD prophylaxis.

About this Canterbury DHB document (9166):

Document Owner:

Andrew Butler (see Who's Who)

Issue Date:

December 2016

Next Review:

December 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 9166