Canterbury DHB

Context

Acute Myeloid Leukaemia

In This Section

Standard Allografts

RIC SCTs

Standard Allografts

The Cyclophosphamide/TBI combination has been used for at least 30 years. Initially TBI was given as a single dose of 12Gy. In later years TBI has been given in a fractionated manner usually over 2-3 days in a total dose of 12-14.4Gy.

The Busulphan/Cyclophosphamide schedule was introduced during the 1980s partly because many units found it difficult to access TBI easily. In general, it has given similar results to Cyclo/TBI at least in myeloid malignancies.

RIC SCTs

In general RIC SCT for myeloid malignancies at Christchurch is undertaken using the Fludarabine/Melphalan/Alemtuzumab protocol. This is one of the two RIC schedules recommended in UK AML 15. See Blood, Oct 2000; 96:2419-2425.

About this Canterbury DHB document (9165):

Document Owner:

Andrew Butler (see Who's Who)

Issue Date:

December 2016

Next Review:

December 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 9165