Canterbury DHB

Context

Peripheral Blood Stem Cell Harvesting and Mobilisation Protocols

In This Section

General Comments

Peripheral Blood Stem Cell Mobilisation Protocols

General Comments

Peripheral blood stem cells are usually obtained after mobilisation with cytokines alone or in combination with chemotherapy.

Factors adversely affecting stem cell reserve include:

In practice often a trial of stem cell harvesting is required and the timing of harvesting is dictated by the kinetics of WBC and CD34+ counts, the yields from previous harvests, and target CD34 numbers required.

Peripheral Blood Stem Cell Mobilisation Protocols

The following protocol is generally used for PBSC harvest. The choice of protocol will be made by the consultant supervising the transplant procedure.

Note: G-CSF may be substituted with Pegylated G-CSF 6 mg single dose on day 3.

PBSC harvest can also be done during recovery after some chemotherapy schedules and these include:

Note: G-CSF is normally given after ICE and IVE in a dose of 5 mcg/kg. If stem cells are to be harvested a higher dose of G-CSF is given (10 mcg/kg).

Note: These 2 schedules can be combined with Rituximab if clinically appropriate.

Other novel agents such as Perixafor (AMD3100) may be considered in exceptional circumstances. However the cost of this agent generally precludes its use.

For current trials, see the Clinical Trials page on the Intranet.

About this Canterbury DHB document (9010):

Document Owner:

Andrew Butler (see Who's Who)

Issue Date:

December 2016

Next Review:

December 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 9010