Canterbury DHB

Context

Cord Blood Transplantation (CBT)

In This Section

Historical Aspects

Indications for Cord Blood Transplantation

Fuller Information about Cord Blood Transplants

Procedure for Harvest of Related Cord Blood Stem Cells

Historical Aspects

The potential value of cord blood transplantation has been known since the early 1970s. Murine studies indicated that umbilical cord blood contained high numbers of primitive haemopoietic cells and that such cells could rescue lethally irradiated syngeneic mice. Subsequent studies confirmed that haemopoietic progenitors exist in large numbers in human cord blood. The lack of a suitable in vitro assay for pluripotential haemopoietic stem cells (PHSC) delayed the development of human CBT.

The first human CBT was performed by Eliane Gluckman on a 5 year old child with Fanconi’s anaemia in 1988 using an HLA-identical related sibling cord blood donation. The successful outcome of this procedure stimulated others to perform such transplants which were carried out on children with inherited conditions/aplasia/ malignancy using sibling related donations which were predominantly HLA identical. This led to the establishment of the International Cord Blood Transplant Registry.

For a review of Cord Blood Transplants (CBT) and the advantages and disadvantages of CBT compared to standard allograft SCT matched sib or MUD see Tse and Laughlin, ASH EPB, 2005.

Indications for Cord Blood Transplantation

Related

This situation will arise rarely, and the indication for CBT will need to be considered on an individual basis.

Unrelated

John's Recommendations (Wagner)

Fuller Information about Cord Blood Transplants

See:

About this Canterbury DHB document (8912):

Document Owner:

Andrew Butler (see Who's Who)

Issue Date:

December 2016

Next Review:

December 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 8912