Canterbury DHB

Context

Donor Searches

Usually the best donor for an allogeneic stem cell transplant is a genotypically HLA-identical sibling of the recipient. The chance of this occurring is 1 in 4 for any given sibling.

Approximately 25-30% of patients in need of a transplant have such a donor. If not, other related HLA-identical or partially identical family members may also be considered as potential donors. In this situation a choice will need to be made between a potential but probably mismatched family donor, a matched unrelated donor (MUD), and CORD stem cells.

In This Section

Sibling Donor Searches

Extended Family Searches (EFS)

One Antigen Mismatched Related SCT

Unrelated Donor (MUD) Searches

Termination of MUD Search

Family Mismatched SCT Donor Search

Sibling Donor Searches

Each of the patient's available siblings should be HLA A and B typed if the patient may require a transplant in the future. It is advisable to ensure that there are no absolute contraindications to using a sibling as a bone marrow donor prior to testing them. Do not forget to tissue type the patient.

Note: It is policy to convey the tissue typing result only to that individual. The result should only be divulged to a third party e.g., potential recipient and or other family members after the individual concerned has given permission.

For further details of sibling donor searches see the following hyperlinks:

Extended Family Searches (EFS)

Guidance will be sought from the Tissue Typing experts as to the appropriateness of an extended family search.

The aim of an extended family search is to explore the possibility that relatives other than siblings may be suitable to act as a bone marrow donor for patients who do not have an HLA identical sibling.

One Antigen Mismatched Related SCT

For further details, see Family Mismatched SCT Donor Search.

Unrelated Donor (MUD) Searches

If no compatible family members are identified then the SCT Committee must decide whether a MUD SCT (or a Cord SCT) is appropriate for an individual patient.

Links

Termination of MUD Search

In the event of SCT Committee deciding that MUD SCT is no longer appropriate for a patient, (e.g., because of death, disease progression, new therapeutic option), the search must be formally terminated using Form 115 (see the SCT Coordinator for this form) in the NZBMDR protocol which should be faxed as soon as possible to the office in Auckland.

This simple measure, which is often overlooked, will prevent wastage of money, time and energy. NZBMDR will then refund or invoice for outstanding funds.

About this Canterbury DHB document (8893):

Document Owner:

Andrew Butler (see Who's Who)

Issue Date:

December 2016

Next Review:

December 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 8893