Canterbury DHB

Context

Conventional Myeloablative Allografts

In This Section

Conventional Myeloablative Protocols

Infection Prophylaxis

GvHD Prophylaxis

Conventional Myeloablative Protocols

The term "conventional" myeloablative conditioning is used to distinguish those regimens which are intensely myelotoxic as well as lymphotoxic and are given with the dual purpose of reducing the disease burden and facilitating engraftment. Typically they would result in long-lasting myelosuppression >28 days if given without stem cell support, are associated with high rates of non-haematological toxicity and result in full chimerism in the majority of patients.

The schedules used most commonly at Christchurch are Cyclophosphamide /TBI, Busulphan/Cyclophosphamide, and Cyclophosphamide + ATG.

Infection Prophylaxis

For infection prophylaxis in SCT, refer to:

GvHD Prophylaxis

About this Canterbury DHB document (8878):

Document Owner:

Andrew Butler (see Who's Who)

Issue Date:

December 2016

Next Review:

December 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 8878