Canterbury DHB
The term "conventional" myeloablative conditioning is used to distinguish those regimens which are intensely myelotoxic as well as lymphotoxic and are given with the dual purpose of reducing the disease burden and facilitating engraftment. Typically they would result in long-lasting myelosuppression >28 days if given without stem cell support, are associated with high rates of non-haematological toxicity and result in full chimerism in the majority of patients.
The schedules used most commonly at Christchurch are Cyclophosphamide /TBI, Busulphan/Cyclophosphamide, and Cyclophosphamide + ATG.
For infection prophylaxis in SCT, refer to:
Topic Code: 8878