Canterbury DHB

Context

DNA Analysis

As indicated in the cytogenetics section, precursor B-cell ALL in adults is often associated with the Philadelphia chromosome, the BCR-ABL fused gene producing a p190 fusion protein. Changes involving the MLL gene are commonly seen in ALL in infancy and in post-chemotherapy acute leukaemias, although most of these are AML in type. EBV DNA can be demonstrated in nearly all cases of Burkitt’s lymphoma. EBV DNA may be present in Burkitt-like ALL but this is much less common (<30%). In precursor T-cell ALL, DNA rearrangements occur in about 30% of cases and have no known prognostic significance. Translocations affecting a, b, and d T-cell receptor loci have all been described. Deletions in TAL1 may also be found.

Gene profiling looking at the expression of large numbers of genes in leukaemic cells may well define other distinct biological types within both precursor B-cell and T-cell ALL groups.

About this Canterbury DHB document (8845):

Document Owner:

Peter Ganly (see Who's Who)

Issue Date:

November 2018

Next Review:

November 2021

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 8845