Canterbury DHB
Any blast cells present in the blood will usually be relatively small with a high nuclear / cytoplasmic ratio and no cytoplasmic granules. These appearances are non-specific. The previous FAB classification of L1, L2, and L3 is no longer used as L1 and L2 morphology do not predict immunophenotype, genetic abnormalities or clinical behaviour. However, Burkitt-like leukaemia does have a characteristic appearance (previously referred to as FAB L3). The blast cells have dark blue vacuolated cytoplasm.
Topic Code: 8841