Canterbury DHB

Context

Aplastic Anaemia

Allogeneic BMT from a human leucocyte antigen (HLA)-identical sibling donor is the initial treatment of choice for newly diagnosed patients if they have severe or very severe aplastic anaemia, are <40 years old and have an HLA-compatible sibling donor. The recommended source of stem cells for transplantation in aplastic anaemia is bone marrow.

Immunosuppressive therapy is generally recommended for (i) patients with non-severe aplastic anaemia who are transfusion dependent (ii) patients with severe or very severe disease who are >40 years old and (iii) younger patients with severe or very severe disease who do not have an HLA-identical sibling donor.

Matched unrelated donor (MUD) BMT may be considered when a patient has severe aplastic anaemia, has no matched sibling donor but a matched unrelated donor, is <50 years old (or 50–60 years old with good performance status), and has failed at least one course of ATG and ciclosporin.

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About this Canterbury DHB document (8157):

Document Owner:

Andrew Butler (see Who's Who)

Issue Date:

December 2016

Next Review:

December 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 8157