Canterbury DHB

Context

Immune Mediated Haemolytic Anaemia

The major causes are summarised below:

Warm reacting antibodies

  • Primary.
  • Secondary (as part of other autoimmune conditions, lymphoproliferative disorders, other malignancies, viral infections).

Cold antibodies, i.e., cold agglutinins, which react best below 37° C

  • Primary
  • Secondary
    • Infection (e.g., mycoplasma, EBV), lymphoproliferative disorders, other malignancies
    • Paroxysmal Cold Haemoglobinuria (the Donath-Landsteiner antibody)

Drug-induced immune mediated haemolysis

Many drugs have been associated with haemolysis and some of these are listed in the table below

Drugs Associated with Haemolysis

Acetaminophen

Isoniazid

a-Methyldopa

Mefenamic acid

Amphotericin B

Melphalan

Carbimazole

Omeprazole

Carboplatin

Penicillins

Cephalosporins

Phenacetin

Chlorpromazine

Quinine

Chlorpropamide

Ranitidine

Cisplatin

Rifampin

Diclofenac

Sulfonamides

Doxepin

Teniposide

Erythromycin

Tetracycline

Ibuprofen

Triameterene

In This Section

Diagnosis and Management

About this Canterbury DHB document (7952):

Document Owner:

Mark Smith (see Who's Who)

Issue Date:

August 2017

Next Review:

August 2019

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 7952