Canterbury DHB


Anaemia of Chronic Inflammation

Patients usually have a haemoglobin of between 70 to 110 g/L and the red cells are either normocytic or microcytic. Reticulocytes are low and there is evidence of inflammation as judged by a raised CRP and changes on protein electrophoresis. See the table in the iron deficiency section for changes in iron levels and ferritin.

Cytokines are increased in inflammation, e.g. TNF-alfa, IL-1 and interferons, and these may all interfere with erythropoiesis. Hepcidin levels are increased in inflammation and this protein can block iron transport at multiple sites and may affect iron incorporation into the developing erythroblast.

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Last Reviewed:

November 2019

Next Review:

November 2022


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Topic Code: 7946