Canterbury DHB

Context

Anaemia of Chronic Inflammation

Patients usually have a haemoglobin of between 70-110g/L and the red cells are either normocytic or microcytic. Reticulocytes are low and there is evidence of inflammation as judged by a raised CRP and changes on protein electrophoresis. See the table in the iron deficiency section for changes in iron levels and ferritin.

Cytokines are increased in inflammation, e.g., TNF-alfa, IL-1 and interferons, and these may all interfere with erythropoiesis. Hepcidin levels are increased in inflammation and this protein can block iron transport at multiple sites and may affect iron incorporation into the developing erythroblast.

About this Canterbury DHB document (7946):

Document Owner:

Mark Smith (see Who's Who)

Issue Date:

August 2017

Next Review:

August 2019

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 7946