
Classification
The WHO Classification appeared in a 4th edition in 2008 and underwent a significant revision in 2016. For a review of the 2016 revision, see Swerdlow, S.H., Campo, E. (2016). "The 2016 revision of the World Health Organization classification of lymphoid neoplasms." Blood 127: 2375-90.
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B-cell lymphomas – 80%
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T-cell lymphomas – 20%
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Indolent
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- CLL/small lymphocytic lymphoma
- Lymphoplasmacytic lymphoma
- Waldenstrom’s macroglobulinemia
- Splenic B-cell marginal zone lymphoma
- Extra-nodal marginal zone B-cell lymphoma of MALT
- Nodal marginal zone lymphoma
- Follicular lymphoma
- Extranodal follicular lymphoma
- Primary intestinal follicular lymphoma
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- Mycosis Fungoides / Sezary syndrome
- Primary cutaneous anaplastic large cell
- Subcutaneous panniculitis-like T-cell lymphoma
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Aggressive
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- Diffuse large B-cell:
- Germinal Centre Cell origin
- Activated B cell origin
- DLBCL, subtypes T-cell/histiocyte rich large B-cell lymphoma (primary DLBCL of CNS and primary cutaneous DLBCL)
- Primary mediastinal (thymic) large B-cell lymphoma
- Intravascular DLBCL
- Lymphomatoid granulomatosis
- ALK-positive DLBCL
- Primary effusion lymphoma
- DLBCL associated with inflammation
- Plasmablastic lymphoma
- Burkitt’s lymphoma
- DLBCL/BL and DLBCL/HL
- Large B-cell lymphoma arising in HHV8 associated with Castleman’s disease
- Precursor B lymphoblastic
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- Anaplastic large cell lymphoma, ALK-positive (ALCL, ALK+)
- Anaplastic large cell lymphoma, ALK-negative (ALCL, ALK-)
- Peripheral T-cell lymphoma, NOS
- Adult T-cell leukaemia / lymphoma
- Extra-nodal NK/T-cell lymphoma, nasal type
- Hepatosplenic T cell lymphoma
- Enteropathy associated T-cell lymphoma
- Angio-immunoblastic T-cell lymphoma
- Precursor T-lymphoblastic
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Topic Code: 6406