Canterbury DHB


Clozapine Induced Neutropenia – Prevention and Management

Clozapine is also one of newer antipsychotic medications. This is currently reserved for treatment resistant schizophrenia. Clozapine is known to cause severe neutropenia (3% of patients develop a WBC<3.5 x 109/L and 0.4% develop neutrophils <0.5 x 109/L). Leucopenia is most likely to occur between three weeks and three months after commencing this medication. It is not thought to be dose related.

See Clozapine Monitoring for details of clozapine monitoring and management of neutropenia if this occurs.

About this Canterbury DHB document (6372):

Document Owner:

Amy Holmes (see Who's Who)

Last Reviewed:

August 2017

Next Review:

August 2019


Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 6372