Canterbury DHB
After excluding secondary causes of eosinophilia, diagnostic evaluation of primary eosinophilias relies on a combination of:
These are required to detect histopathologic or clonal evidence for an acute, chronic myeloid, or lymphoproliferative disorder.
Chronic eosinophilic leukaemia NOS is an MPN, but the 2016 WHO classification includes a new category called myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement. This includes patients who have haematologic malignancy (e.g. MPN, AML, ALL, CMML) with eosinophilia and rearrangements of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2.
See the flow chart from the 2017 BCSH guidelines,1 figure 1 page 11 for an algorithm for the work up of presumed clonal eosinophilia.
Topic Code: 6259