Canterbury DHB

Context

Causes of Eosinophilia

After excluding secondary causes of eosinophilia, diagnostic evaluation of primary eosinophilias relies on a combination of:

These are required to detect histopathologic or clonal evidence for an acute, chronic myeloid, or lymphoproliferative disorder.

Chronic eosinophilic leukaemia NOS is an MPN, but the 2016 WHO classification includes a new category called myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement. This includes patients who have haematologic malignancy (e.g. MPN, AML, ALL, CMML) with eosinophilia and rearrangements of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2.

See the flow chart from the 2017 BCSH guidelines,1 figure 1 page 11 for an algorithm for the work up of presumed clonal eosinophilia.

About this Canterbury DHB document (6259):

Document Owner:

Sean Macpherson (see Who's Who)

Issue Date:

August 2018

Next Review:

April 2021

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 6259