Canterbury DHB

Context

Chronic Eosinophilic Leukaemia – Not Otherwise Specified (CEL-NOS)

This is a rare myeloproliferative neoplasm characterised by a gradual increase in circulating eosinophils (≥ 1.5 x 109/L), usually with cytologic atypia, left-shifted granulocytic maturation, and often hepatomegaly, or splenomegaly. Blast may be increased, but must be <20% (exclude core binding factor AML), and other haematologic neoplasms must be excluded as per the WHO diagnostic criteria below. Patients with CEL may develop organ damage as a result of infiltration and release of eosinophilic granules that contain cytokines and humoral factors. Fatal cardiac disease has also been described.

About this Canterbury DHB document (6247):

Document Owner:

Sean Macpherson (see Who's Who)

Issue Date:

August 2018

Next Review:

April 2021

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 6247