Canterbury DHB
This is a rare myeloproliferative neoplasm characterised by a gradual increase in circulating eosinophils (≥ 1.5 x 109/L), usually with cytologic atypia, left-shifted granulocytic maturation, and often hepatomegaly, or splenomegaly. Blast may be increased, but must be <20% (exclude core binding factor AML), and other haematologic neoplasms must be excluded as per the WHO diagnostic criteria below. Patients with CEL may develop organ damage as a result of infiltration and release of eosinophilic granules that contain cytokines and humoral factors. Fatal cardiac disease has also been described.
Topic Code: 6247