Canterbury DHB
Essential thrombocythaemia (ET) is the commonest MPN, and is predominantly characterised by excessive clonal megakaryocyte production and thrombocytosis.
Most cases occur in people aged between 50–60 years, although it can occur in young adults.
Fifty per cent of patients are asymptomatic, and are diagnosed following a routine FBC check.
The other 50% present with either:
Patients with constitutional symptoms and splenomegaly are more likely to have fibrotic changes on trephine.
Of ET patients:
Topic Code: 6233