Canterbury DHB



Chronic Phase (CP)

Accelerated Phase (AP)

The 2016 WHO criteria2 for the diagnosis of the accelerated phase of CML includes response to TKI therapy, see table 2, page 3.

Blast Phase (BP)

Defined by ≥20% blasts in peripheral blood or bone marrow or proliferation of extramedullary blasts.

The majority of BPs are of myeloid lineage, but 20-30% of cases are lymphoblaststic (usually B-cell). Sequential lymphoid then myeloid blasts crisis have been reported.

80% of patients in BP show clonal evolution.

About this Canterbury DHB document (6215):

Document Owner:

Bridgett McDiarmid (see Who's Who)

Last Reviewed:

August 2018

Next Review:

April 2021


Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 6215