Canterbury DHB

Context

Morphology

Chronic Phase (CP)

Accelerated Phase (AP)

The 2016 WHO criteria2 for the diagnosis of the accelerated phase of CML includes response to TKI therapy, see table 2, page 3.

Blast Phase (BP)

Defined by ≥20% blasts in peripheral blood or bone marrow or proliferation of extramedullary blasts.

The majority of BPs are of myeloid lineage, but 20-30% of cases are lymphoblaststic (usually B-cell). Sequential lymphoid then myeloid blasts crisis have been reported.

80% of patients in BP show clonal evolution.

About this Canterbury DHB document (6215):

Document Owner:

Sean Macpherson (see Who's Who)

Issue Date:

August 2018

Next Review:

April 2021

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 6215