Canterbury DHB

Context

Management of Extravasation of Cytotoxic Drugs

In the event of extravasation of any cytotoxic drug, vesicant or irritant:

See the CDHB Cytotoxic and Biotherapy Procedures on administration, safe handling, and disposal of cytotoxic drugs. This must be referred to for full details. Please read before administering chemotherapy.

In This Section

Vesicant Drugs

Irritant Drugs (This List is Not Exhaustive)

Vesicant Drugs

Vesicant drugs are capable of causing extensive tissue necrosis, ulceration, and pain.

Examples of DNA - BINDING (this list is not exhaustive)

Amsacrine

Epirubicin

Mitomycin C

Dactinomycin

Idarubicin

Mitoxantrone
(irritant with vesicant properties)

Daunorubicin

Melphalan
(irritant with vesicant properties)

Paclitaxel
(irritant with vesicant properties)

Doxorubicin

 

 

Examples of NON DNA - BINDING (this list is not exhaustive)

Vinblastine

Vincristine

Vinorelbine

For extravasation of vesicant drugs, use a cold ice compress to the area for 15 minutes (except vincristine, vinblastine, or vinorelbine). This should be repeated four times a day, avoiding undue pressure.

For vinca alkaloids (vincristine, vinblastine, and vinorelbine) use a warm compress instead.

Irritant Drugs (This List is Not Exhaustive)

Irritant drugs are likely to cause inflammation, pain, and swelling, but the effects are less severe than with DNA-binding vesicant drugs.

Extravasation of any of these drugs requires a cold compress to the area for 30 minutes, avoiding any undue pressure. Give pain relief as required.

Note: A Safety First Incident Form (CDHB) must be completed when extravasation of a cytotoxic drug occurs.

About this Canterbury DHB document (5724):

Document Owner:

Steve Gibbons and Fiona Stone (see Who's Who)

Issue Date:

March 2017

Next Review:

March 2020

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 5724