Canterbury DHB


POEMS Syndrome

Also known as “Osteosclerotic myeloma”, “Crow-Fukase syndrome”, “Takatsuki syndrome”.

POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes) is a plasma cell dyscrasia featuring:

Other features include:

POEMS should be distinguished from MGUS associated neuropathy and from CIDP as the management is different.

Patients with POEMS syndrome are younger (median age 51 years) and have longer average survivals (median 8 years) than those with symptomatic myeloma. The clinical course is commonly one of progressive neuropathy which may respond to treatment for myeloma.

Treatment is as per myeloma.

See ASH EPB, p. 360, Review of POEMS, Dispenzieri, 2005.

About this Canterbury DHB document (5613):

Document Owner:

Amy Holmes (see Who's Who)

Last Reviewed:

September 2014

Next Review:

September 2016


Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 5613