Canterbury DHB
Also known as “Osteosclerotic myeloma”, “Crow-Fukase syndrome”, “Takatsuki syndrome”.
POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes) is a plasma cell dyscrasia featuring:
Other features include:
POEMS should be distinguished from MGUS associated neuropathy and from CIDP as the management is different.
Patients with POEMS syndrome are younger (median age 51 years) and have longer average survivals (median 8 years) than those with symptomatic myeloma. The clinical course is commonly one of progressive neuropathy which may respond to treatment for myeloma.
Treatment is as per myeloma.
See ASH EPB, p. 360, Review of POEMS, Dispenzieri, 2005.
Topic Code: 5613