
Diagnostic Criteria
The WHO 2007 diagnostic criteria are now the same as the International Myeloma Working Group, as found in BJH 2003 121(5) p749-757. These are, in short:
- The presence of an M protein in serum or urine (any level)
- Bone marrow (clonal) plasma cells OR plasmacytoma (any level)
- Related Organ or Tissue Impairment (ROTI)
- C Calcium increased (>2.75 mmol/L)
- R Renal insufficiency (>173 mmol/L with no other cause)
- A Anaemia (20 g/L below normal range)
- B Bone lesions
- O Other, i.e. hyperviscosity, amyloid, recurrent infections, etc.
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Topic Code: 5583