
Diagnostic Criteria for CEL
Diagnostic criteria for CEL (WHO 2016)
- Persistent eosinophilia (≥ 1.5 x 109/L) in which reactive causes have been excluded
- Does not meet diagnostic criteria for chronic myeloid leukemia with:
- t(9;22)(q34.1;q11.2) / BCR-ABL1 gene fusion
- polycythaemia vera
- essential thrombocythaemia
- primary myelofibrosis
- chronic neutrophilic leukemia
- chronic myelomonocytic leukemia
- atypical chronic myeloid leukemia (BCR-ABL1 gene fusion negative)
- systemic mastocytosis
- Blasts < 20% of peripheral blood and bone marrow cells and does not have the following cytogenetic aberrations:
- PDGFRA, PDGFRB or FGFR1 rearrangements
- t(8;9)(p22;p24.1) / PCM1-JAK2, t(9;12)(p24.1;p13.2) / ETV6-JAK2 or t(9;22)(p24.1;q11.2) / BCR-JAK2 fusions
- inv(16)(p13.1;q22) or t(16;16)(p13.1;q22) / CBFB / MYH11, t(15;17)(q22;q11-12) / PML-RARA or t(8;21)(q22;q22.1) / RUNX1 / RUNX1T1
- t(9;22)(q24;q31) / BCR-ABL1 fusions
- Presence of clonal cytogenetic or molecular genetic abnormality(ies),* or a blast count ≥ 2% in the peripheral blood or ≥ 5% in the bone marrow
*Certain gene mutations (e.g. DNMT3A, TET2, ASXL1 with variant allele frequency ≥ 2%) can be seen in a subpopulation of elderly patients who do not have haematologic disorders, otherwise known as clonal haematopoiesis of indeterminate potential. Therefore, diagnostic interpretation should be done with caution.2,3
Topic Code: 537414