Canterbury DHB


Chronic Neutrophilic Leukaemia (CNL)

This is a rare MPN characterised by chronic neutrophilia, and marrow hypercellularity due to granulocyte proliferation and hepatosplenomegaly.

Diagnostic criteria


See Tefferi A, et al. (2016), table 1, page 3 for diagnostic criteria for CNL.

Chronic phase, accelerated phase, and blast phase

In CNL, a chronic phase, accelerated phase and a blast phase can be recognised (like CML). The chronic phase disease has typically been treated as needed with cytoreductive therapy, such as hydroxyurea.

Disease acceleration often manifests with:

Blast transformation, which to date has been exclusively reported as myeloid, occurs in a significant proportion (20%) of patients at a median of 21 months from diagnosis. The reported median survival of all patients is under 2 years.

About this Canterbury DHB document (532917):

Document Owner:

Bridgett McDiarmid (see Who's Who)

Last Reviewed:

August 2018

Next Review:

April 2021


Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 532917