Canterbury DHB

Context

Doses of FVIII-VWF Concentrate (Biostate) for VWF Patients Unresponsive to desmopressin (avail. from Blood Bank)

A recommended dosage schedule is as follows:

Type of Bleeding

Dose (IU/kg) of FVIII

Number of Infusions

Objective

Major Surgery

20-40

once a day or every other day

maintain FVIII >50% until healing is complete

Minor Surgery

15

once a day or every other day

FVIII >30% until healing is complete

Dental Extractions

15

single

FVIII >30% for up to 6 hrs

Spontaneous or Post-traumatic Bleeding

15

single

 

Bleeding is usually controlled, provided adequate (>50%) FVIII levels are maintained, irrespective of the bleeding time. Attention to local haemostasis (sutures, cautery, wound packing) is essential perioperatively. Consider also tranexamic acid, 1g TDS PO for superficial surface bleeding.

About this Canterbury DHB document (5279):

Document Owner:

Mark Smith (see Who's Who)

Issue Date:

August 2016

Next Review:

August 2019

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 5279