Canterbury DHB
A recommended dosage schedule is as follows:
Type of bleeding |
Dose (IU/kg) of FVIII |
Number of infusions |
Objective |
Major surgery |
20 to 40 |
once a day or every other day |
maintain FVIII > 50% until healing is complete |
Minor surgery |
15 |
once a day or every other day |
FVIII > 30% until healing is complete |
Dental extractions |
15 |
single |
FVIII > 30% for up to 6 hours |
Spontaneous or post-traumatic bleeding |
15 |
single |
|
Bleeding is usually controlled, provided adequate (> 50%) FVIII levels are maintained, irrespective of the bleeding time. Attention to local haemostasis (sutures, cautery, wound packing) is essential peri-operatively. Consider also tranexamic acid, 1 g three times a day PO for superficial surface bleeding.
Topic Code: 5279