Canterbury DHB
Aim: To prevent spontaneous bleeding.
This is generally achieved by a peak factor VIII of 40%.
Variable schedule is daily to two or three times weekly, depending on whether a short or longer half-life product is used. A higher dose may be needed on Friday. 72 hrs before next dose.
In patients with a shorter half-life or breakthrough bleeds, the dosing should be increased. A dose between 25 u and 40 u/kg/dose may be required. Dosing on alternate days should be considered if breakthrough bleeds are a problem. It is advisable to calculate the recovery and half-life in all cases. In some patients, it may be necessary to individualise the treatment protocol and recommend treatment as frequently as once daily.
Topic Code: 5237