Canterbury DHB

Context

Diagnosis of DIC

This requires the demonstration of:

Because of the opposite effects of activation of clotting factors and consumption of clotting factors, the clotting test, APTT, may be short or long. The PT and TT are usually prolonged. Fibrinogen and platelets should be reduced compared to pre DIC levels (which may have been high). Therefore a “normal” result may not exclude a fall in levels. For this reason, serial tests some hours apart are often helpful.

Elevation of levels of D-dimer, a breakdown product of fibrin, is a sign that both clotting and fibrinolysis have occurred. Significant elevations of D-dimer are usually seen in DIC. Some of these above changes may also be seen to a degree in major venous thrombosis.

About this Canterbury DHB document (5217):

Document Owner:

Mark Smith (see Who's Who)

Issue Date:

August 2016

Next Review:

August 2018

Keywords:

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Topic Code: 5217