Canterbury DHB

Context

Pathophysiology

The clotting process involves activation and consumption of coagulation factors and platelets, with the production of a fibrin-platelet thrombus. Normally, this is at the site of vessel injury. This clotting process is balanced by natural anti-coagulant factors (e.g. AT111 and protein C). The clot is lysed by the fibrinolytic system (alteplase, plasmin(ogen)).

In pathological states, macroscopic clots may form in the vascular lumen - arterial or venous. In other pathological states, microscopic clots occur in small blood vessels. These are usually quickly lysed by plasmin. As a result, thrombotic features may be not very apparent but there can be major changes in the clotting factors due to consumption. Microthrombi may present as poor tissue perfusion/function, commonly renal.

About this Canterbury DHB document (5216):

Document Owner:

Mark Smith (see Who's Who)

Issue Date:

August 2016

Next Review:

August 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 5216