
Indications for IVIG usage
The haematological indications for prescribing IVIG can be classified as follows.
Replacement Therapy
- Primary immunodeficiency.
- Myeloma and chronic lymphocyte leukaemia with severe secondary hypogammaglobulinaemia (IgG <5 g/L) and recurrent infections.
- Congenital or acquired humoral immunodeficiency syndrome with recurrent infections.
Therapeutic Treatment
- Idiopathic thrombocytopenic purpura (ITP) in adults or children at high risk of bleeding or prior to surgery to correct the platelet count.
- Kawasaki disease.
- Guillian Barre Syndrome.
- Chronic inflammatory demyelinating polyneuropathy.
- Pure red cell aplasia caused by parvovirus B19.
- Antenatal treatment of neonatal alloimmune thrombocytopenia, a maternal infusion, 1000 mg/kg/week from 20 weeks' gestation.
For further information, please see Criteria for the clinical use of intravenous immunoglobulin.
Topic Code: 5144