Canterbury DHB

Context

Transfusion Related Acute Lung Injury (TRALI)

In This Section

Pathophysiology

Clinical Signs

Laboratory Diagnosis and Evaluation

Management

Pathophysiology

This is sometimes referred to as non-cardiogenic pulmonary oedema, or pulmonary type transfusion reaction. Most commonly, it is due to donor white cell (granulocyte) antibodies reacting with patient leucocytes. Less commonly, the leucocyte antibodies are present in the patient and react with the granulocytes in the transfused unit, usually only with granulocyte transfusions. With both mechanisms, large quantities of leucocyte aggregates are formed, and become trapped in the pulmonary capillaries with subsequent leucocyte and complement activation and immune response.

Clinical Signs

Laboratory Diagnosis and Evaluation

Standard transfusion reaction investigations are negative.

Management

About this Canterbury DHB document (5118):

Document Owner:

Steve Gibbons (see Who's Who)

Issue Date:

August 2014

Next Review:

August 2016

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 5118