Canterbury DHB


Nausea and Vomiting

Chemicals in the blood stream can cause nausea by affecting the Chemoreceptor Trigger Zone (CTZ) in the brain. The CTZ feeds in to the “Vomit Centre” in the brain which also receives signals from the ear, the GI tract and the higher centres. The following neurotransmitter receptors are found.


Vomit centre

Dexamethasone has high grade evidence for its efficacy but the mechanism is unknown.

When using combination therapy, the 6 main drugs listed above are therefore recommended to maximise blockage of each receptor.

Aprepitant is registered for use in New Zealand but is relatively expensive at $116 for 3 days.

In This Section


Chemotherapy and Emetogenic Potential

Cytotoxic Schedules and Choice of Antiemetics

Breakthrough Nausea and Vomiting

Antiemetics for Outpatients

About this Canterbury DHB document (5064):

Document Owner:

Sean Macpherson (see Who's Who)

Last Reviewed:

January 2019

Next Review:

January 2022


Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 5064