Canterbury DHB
Chemicals in the blood stream can cause nausea by affecting the Chemoreceptor Trigger Zone (CTZ) in the brain. The CTZ feeds in to the “Vomit Centre” in the brain which also receives signals from the ear, the GI tract and the higher centres. The following neurotransmitter receptors are found.
Dexamethasone has high grade evidence for its efficacy but the mechanism is unknown.
When using combination therapy, the 6 main drugs listed above are therefore recommended to maximise blockage of each receptor.
Aprepitant is registered for use in New Zealand but is relatively expensive at $116 for 3 days.
Topic Code: 5064