Canterbury DHB

Context

Toxoplasmosis - Treatment

Toxoplasmosis can complicate prolonged and intensive anti-leukaemic chemotherapy of any type but is most likely to occur post-BMT. It is caused by toxoplasma gondii. Toxoplasmosis in BMT recipients occurs as a result of reactivation of latent cysts in seropositive patients following allogeneic transplantation. It usually occurs in the first six months post-BMT. Patients who develop chronic GvHD remain immunocompromised and are at increased risk for toxoplasmosis. See UpToDate website for general information about toxoplasma.

In This Section

Clinical Features

Clinical Features

Toxoplasmosis is a mild condition in patients with normal immune systems. By contrast Toxoplasmosis in the immunosuppressed patient is often life-threatening. In this situation pneumonia, encephalitis, myocarditis, or fever without obvious cause may occur. There are no specific findings but the patient may have neutrological symptoms or the picture may resemble miliary TB or pneumocystis infection.

Diagnosis

Treatment

Note: It is important to start treatment early.

For more information on Pyrimethamine, sulphadiazine, and clindamycin, contact the Haematology pharmacist.

About this Canterbury DHB document (5024):

Document Owner:

Ruth Spearing and Sarah Metcalfe (see Who's Who)

Issue Date:

November 2016

Next Review:

November 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 5024