Canterbury DHB

Context

Treatment of Herpetic Infections

Always try to establish the cause with the appropriate viral studies.

In This Section

Herpes Simplex

Herpes Zoster

Aciclovir - Dosage in Renal Impairment

Herpes Simplex

Valaciclovir is the treatment of choice. Oral therapy is usually adequate but IV aciclovir treatment will be needed for serious infection, e.g. encephalitis or ophthalmic lesions. For topical treatment, there is no good evidence that aciclovir is any better than povidone iodine. Treatment should be given until satisfactory resolution of the lesion(s) has been achieved. Long-term treatment may be needed in some situations.

If intravenous aciclovir needs to be given, prescribe 5 mg/kg Q8H IV.

For more information about oral valaciclovir and IV aciclovir, refer to the Data Sheets on Medsafe.

Herpes Zoster

Intravenous aciclovir is the treatment of choice. To be effective, treatment should be started early, certainly within 48-72 hours of clinical onset.

Dose: 10-12 mg/kg corrected for nearest 250 mg vial three times a day is recommended for IV use. Treatment should be given for at least 7-10 days. Switch to PO valaciclovir when clinically improving.

Note: The dose of aciclovir should be reduced in renal failure.

Oral valaciclovir 1000 mg TDS may be used in patients with uncomplicated shingles.

For more information about oral valaciclovir and IV aciclovir, refer to the Data Sheets on Medsafe.

Aciclovir - Dosage in Renal Impairment

Note: If the creatinine clearance is less than 10 mL/min, seek consultant advice.

Refer to the the Valaciclovir and Aciclovir Data Sheets on Medsafe.

About this Canterbury DHB document (5014):

Document Owner:

Ruth Spearing and Sarah Metcalfe (see Who's Who)

Issue Date:

November 2016

Next Review:

November 2018

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 5014