Canterbury DHB
This varies to some extent in the published literature. The following criteria are commonly used:
Severe AA:
Note: 2 out of the 3 peripheral blood criteria combined with a hypoplastic bone marrow establishes the diagnosis of AA.
Note: Very severe AA - the above criteria apply but with a neutrophil count < 0.2 x 109/L.
Moderate AA:
When only supportive care is given, AA carries a mortality rate of 80 to 90%.
Following ATG and cyclosporin variable results have been reported from a median survival of 6 years to a 58% survival at 11 years.
Long-term, MDS, AML, and PNH may occur in 5 to 10% of patients who respond to immunosuppression.
By contrast, a stem cell transplant is curative, with long-term survival between 60% and 90%.
Patients aged under 16 years do best with an allograft and the results become less good over the age of 25.
Topic Code: 4923