Canterbury DHB

Context

Clinical Presentation

Aplastic Anaemia (AA) is typically seen in young adults, and in this age group, late onset Fanconi anaemia will need to be considered. There is a second peak in incidence over the age of 50, and at this age, AA needs to be distinguished from hypocellular MDS/AML.

Symptoms and signs secondary to anaemia, neutropenia, and thrombocytopenia are usually present and the onset may be quite abrupt. Often, the patient is generally well. On examination, there is no enlargement of liver, spleen, or lymph nodes.

In Fanconi Anaemia, obvious congenital abnormalities (including patchy areas of increased skin pigmentation) may be seen.

It is important to take a complete history of any drug or chemical exposure or of any infections that may have occurred over the preceding 12 months. For example, there may be a delay of some months following an attack of hepatitis before the onset of AA.

About this Canterbury DHB document (4920):

Document Owner:

Mark Smith (see Who's Who)

Issue Date:

August 2017

Next Review:

August 2019

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 4920