Canterbury DHB


Supportive Care

In This Section

Differentiation (ATRA) syndrome

Other Side Effects of Tretinoin (ATRA)

Differentiation (ATRA) syndrome

Diagnosis of the differentiation (ATRA) syndrome should be suspected clinically in the presence of one of the following symptoms and signs:

We recommend checking O2 saturations initially at least 4-hourly until white count has dropped, then 8-hourly while an inpatient, or more often if there are any respiratory symptoms. The following account of the ATRA Syndrome is taken from Sanz, M. A., M. S. Tallman, et al. (2005). Tricks of the trade for the appropriate management of newly diagnosed acute promyelocytic leukemia. Some minor modifications have been made.

Other Side Effects of Tretinoin (ATRA)

About this Canterbury DHB document (4484):

Document Owner:

Blake Hsu (see Who's Who)

Last Reviewed:

October 2018

Next Review:

October 2020


Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 4484