
Induction
AIDA Protocol:
- Tretinoin (ATRA) 45 mg/m2/day PO in 2 divided doses daily until haematological complete remission (HCR) or for a maximum of 60 days.
- Idarubicin 12 mg/m2 by short (20 minute) infusion on days 2, 4, 6, and 8 (four doses). If WBC count > 10 X 109/L, start idarubicin on day 1, within a few hours of starting tretinoin.
Continue tretinoin if marrow appearances are equivocal at day 30. If HCR is not achieved by 60 days, take the patient off the study and consider other treatment such as arsenic.
Topic Code: 4367