Canterbury DHB
After achieving haematological CR, patients will receive 3 successive courses of consolidation chemotherapy and tretinoin (ATRA).
Each cycle will start at haematological recovery, i.e ANC > 1.5 X 109/L and platelets >100 X 109/L.
Cycle 1 |
Tretinoin 45 mg/m2/day PO in 2 divided doses from day 1-15. Idarubicin 5 mg/kg/day by short (20 minute) infusion on days 1-4 (four doses). |
Cycle 2 |
Tretinoin 45 mg/m2/day PO in 2 divided doses from day 1-15. Mitoxantrone 10 mg/m2/day as 30 minute infusion on days 1-5 (five doses). |
Cycle 3 |
Tretinoin 45 mg/m2/day PO in 2 divided doses from day 1-15. Idarubicin 12 mg/m2 by short (20 minute) infusion on day 1. |
Topic Code: 4305