
Idarubicin / Cytarabine Protocol
This is a less intensive regimen that may be considered.
Pre-treatment Assessment
- Get LVEF before starting treatment. If >10% reduction from the admission baseline LVEF, discuss with the Consultant.
- Consider administering Idarubicin days 1 and 2 only.
- Allopurinol 300 mg daily. Modify if creatinine raised.
- Check Na, K, creatinine, glucose, Ca, urate, alb, bili, alk phos, ALT.
Dose Modifications
Bilirubin
|
% dose Idarubicin
|
<25
|
100%
|
26–50
|
50%
|
>50
|
Do not give
|
Initial Treatment
- Idarubicin 12 mg/m2 days 1, 2, and 3. IV bolus over 10-15 minutes into fast running saline.
- Cytarabine 600 mg/m2 BD days 1-6 given as:
- Cytarabine 100 mg/m2 IV bolus followed by Cytarabine 500 mg/m2 in 5% dextrose (or 0.9S) over 3 hours.
Note: A copy of the prescription sheet for Idarubicin / Cytarabine is available. You must print this out and use it for the prescription to be sent to Pharmacy.
Chart Prednisolone eyedrops 0.1% TDS for 10 days starting 12 hours prior to Cytarabine.
Topic Code: 4293