Canterbury DHB

Context

Higher Risk MGUS

The higher the paraprotein level, the less likely that the diagnosis will be MGUS. IgG levels above 21g/L and IgA levels above 16g/L correlate with bone marrow plasma cell burdens of greater than 10% and bone marrow biopsies are likely to be more useful above these levels. A Bone marrow biopsy is also indicated at lower levels of paraprotein if other findings suggest myeloma.

IgM paraprotein levels do not correlate with bone marrow disease burden and should not be used to guide the decision to perform a bone marrow biopsy.

Non-IgG MGUS paraproteins are deemed higher risk.

Other tests useful to exclude myeloma and to assess MGUS prognosis include

About this Canterbury DHB document (39808):

Document Owner:

Sean Macpherson (see Who's Who)

Issue Date:

September 2014

Next Review:

September 2016

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 39808