Canterbury DHB

Context

Assessment of M proteins

The majority (72%) of patients with a new monoclonal protein will have MGUS. This is defined by the presence of a monoclonal protein of less than 30 g/L, a bone marrow plasma cell infiltrate of less than 10%, and the absence of anaemia, hypercalcaemia, lytic bone lesions, and renal failure attributable to a plasma cell disorder.

A detailed history and examination should include enquiry for symptoms associated with myeloma (bone pain), amyloid (heart failure, macroglossia, peripheral neuropathy, carpal tunnel syndrome, nephrotic syndrome) and lymphoproliferative diseases (night sweats, fevers, weight loss, lymphadenopathy, hepatosplenomegaly).

Patients with a new monoclonal protein should undergo initial testing including

About this Canterbury DHB document (39806):

Document Owner:

Sean Macpherson (see Who's Who)

Issue Date:

September 2014

Next Review:

September 2016

Keywords:

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Topic Code: 39806