Canterbury DHB


Management of elderly patients with lymphoma

There is debate over the upper age limit of treatment for lymphoma and especially aggressive non-Hodgkin’s lymphoma. Elderly could be used to define patients by age, e.g. over 70 or 75 years, or by function, i.e. those who are not expected to undergo standard chemotherapy without excessive risk. CHOP chemotherapy may be dose reduced in older or frailer patients and become more tolerable while retaining some valuable efficacy. See Peyrade, F., et al. (2011). "Attenuated immunochemotherapy regimen (R-miniCHOP) in elderly patients older than 80 years with diffuse large B-cell lymphoma: a multicentre, single-arm, phase 2 trial." Lancet Oncol 12(5): 460-468.

Further reading

Cordoba R, Eyre TA, Klepin HD, Wildes TM, Goede V. A comprehensive approach to therapy of haematological malignancies in older patients. Lancet Haematol 2021;8(11):e840-e852. DOI: 10.1016/S2352-3026(21)00241-6.

About this Canterbury DHB document (33790):

Document Owner:

Peter Ganly (see Who's Who)

Last Reviewed:

December 2021

Next Review:

December 2024


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Topic Code: 33790