Canterbury DHB

Context

Sorror Score before Transplant

In This Section

Table 1. Definitions of comorbidities included in the HCT-CI

Table 2. HCT-CI scores, 2 year survival and hazard ratios for NRM (Non-Relapse Mortality)

Table 1. Definitions of comorbidities included in the HCT-CI

Comorbidity

Definitions of comorbidities included in the new HCT-CI

HCT-CI weighted scores

Arrhythmia

Atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias

1

Cardiac

Coronary artery disease*, congestive heart failure, myocardial infarction, or EF Less than or equal to sign 50%

1

Inflammatory bowel disease

Crohns disease or ulcerative colitis

1

Diabetes

Requiring treatment with insulin or oral hypoglycemics but not diet alone

1

Cerebrovascular disease

Transient ischemic attack or cerebrovascular accident

1

Psychiatric disturbance

Depression or anxiety requiring psychiatric consult or treatment

1

Hepatic, mild

Chronic hepatitis, bilirubin > ULN to 1.5 x ULN, or AST/ALT > ULN to 2.5 x ULN

1

Obesity

Patients with a body mass index > 35 kg/m2

1

Infection

Requiring continuation of antimicrobial treatment after day 0

1

Rheumatologic

SLE, RA, polymyositis, mixed CTD, or polymyalgia rheumatica

2

Peptic ulcer

Requiring treatment

2

Moderate/severe renal

Serum creatinine > 2 mg/dL, on dialysis, or prior renal transplantation

2

Moderate pulmonary

DLco and/or FEV1 66%-80% or dyspnea on slight activity

2

Prior solid tumor

Treated at any time point in the patient's past history, excluding nonmelanoma skin cancer

3

Heart valve disease

Except mitral valve prolapse

3

Severe pulmonary

DLco and/or FEV1 Less than or equal to sign 65% or dyspnea at rest or requiring oxygen

3

Moderate/severe hepatic

Liver cirrhosis, bilirubin > 1.5 x ULN, or AST/ALT > 2.5 x ULN

3

*One or more vessel-coronary artery stenosis requiring medical treatment, stent, or bypass graft.

Table 2. HCT-CI scores, 2 year survival and hazard ratios for NRM (Non-Relapse Mortality)

 

NRM

Score

HR* (95% CI)

2-year, %

0

1

14

1

1.57 (0.7-3.3)

22

2

1.26 (0.6-2.8)

19

3

3.95 (2.1-7.5)

41

4 or more

3.05 (1.5-6..2)

40

*Adjusted for age, disease risk, and conditioning.

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About this Canterbury DHB document (10195):

Document Owner:

Sean Macpherson (see Who's Who)

Issue Date:

January 2019

Next Review:

January 2022

Keywords:

Note: Only the electronic version is controlled. Once printed, this is no longer a controlled document. Disclaimer

Topic Code: 10195